Sunday, July 29, 2012

Stanley Garage Door Opener Products ... - Home Improvement Zones

Read more about Stanley garage door opener products, specifications and features. Then see what else is normal people are buying and what they think afterwards.

First a little background before we start ?

For homeowners jump right in the products, specifications and features are a short introduction is in order. Stanley began his business in 1843, that they already have more than a century. The company was founded in Connecticut by Frederick Stanley to find solutions for people who iron fittings supplies needed to find.

Earn money from metals in that time was a challenge because the technology is very limited. But if the average homeowner in the technology evolved and garage door openers are relatively common in American homes today.

Modern door openers are very safe, reliable and durable. This is primarily because both parts and labor from the CPSC (Consumer Product Safety Commission) regulates. Only 30 years ago this was not the case. At that time, consumers should be especially careful if you avoid personal injury or death.

The product ?

It is important to note that in Stanley garage door parts specialist. Homeowners can not return home electronic security, door control, or control systems in their range. A homeowner will find:

+ Remote stations
+ Openers
+ Small and Remote
+ Compatibles
+ Secure Code Transmitter
+ Heavy lifting cables
+ Pulleys and forks
+ Overhead door hinges
+ Safety Components feathers

Technical data ?

Now most guides written for homeowners to list items to take or what diet is necessary to mention. Anyway, this information is not very useful for consumers. Instead, what will be useful to just over compatibility. Stanley is unique because it is a special series of products to be made compatible with other manufacturers of other parts and accessories. Consumers should look for ?Compatibles by Stanley ?, as they worry about it.

Their products meet the ADA and the Civil Rights Act, so they can be used by disabled people. Stanley puts a lot of attention to safety. Each room has a normally closed sensor obstacle that prevents the door closed when he feels that something is blocking the way.

Features ?

There are a few characteristics distinguish when we look at the Stanley product line. Backlight, extended warranties and protection against weather and wireless models are available upon request.

This manufacturer also provides keyboards that control of the owner leaves the door inside the garage. Consumers may be interested in the following positions at Stanley Wireless Keypad 2986 310, multi-code technology, and Stanley 49 522 pictures to the eye margin of safety to seek protection.

What people buy ?

Along with the opener, buy keychain remotes, two-and / or three-button clicker and receivers often.

Reviews ?

Online Customer reviews shows that people feel very good about this brand. Eighty-three percent of respondents gave positive answers: The range of products they offer, products, energy efficient, affordable. Approximately fifteen percent gave a neutral or negative comments, including: the warranty is not long enough to reach (130 feet) is too short, or compatibility problems.

Source: http://www.magellanmmgeo.com/1181/stanley-garage-door-opener-products-specifications-and-customer-reviews

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UN Fails to Reach Consensus on Arms Trade Treaty | Morocco ...

Bu April Warren

Morocco World News

United Nations, New York, July 28, 2012

Despite four weeks of negotiations at United Nations headquarter in New York City, members of the international community have failed to reach enough of a consensus for an international Arms Trade Treaty.

?Our conference has been a sporting event,? said Argentinean Ambassador Roberto Garcia Moritan, the conference chairman.? ?We have to compete in the shortest amount of time possible, a series of fixed hurdles, some perhaps a bit too high.?

If adopted, the treaty would have set a common standard to regulate the international trade in conventional arms.

Despite a month-long July negotiation, delegations from 192 states did not receive the first draft of the final treaty until four days before the end of the conference.? This allowed for countries that were wary of a treaty from the start to stall negotiations on the basis that they needed more time.

United Nations Secretary General Ban Ki-moon called the conclusion of the conference ?disappointing.?

?A strong treaty would rid the world of the appalling human cost of the poorly regulated international arms trade, Ban said.? ?It would also enhance the ability of the United Nations to cope with the proliferation of arms.?

A push for the treaty first started in 2006 as a result of the combined efforts Argentina, Australia, Costa Rica, Japan, Kenya, Finland and the United Kingdom.

The current text puts forth state-implemented rules that would regulate and control international transfers of conventional arms and would call on states to set, establish and implement a national export control system.? The treaty would apply to battle tanks, armored combat vehicles, combat aircraft, large-caliber artillery systems, attack helicopters, warships, missiles and missile launchers and small arms and light weapons.? Another area of the treaty also seeks to address ammunition.

This week many delegations voiced concerns over different aspects of the text, which the chairman tried to address by breaking the conference into small groups, but on Friday no breakthroughs were made.

Friday morning New Zealand voiced concerns with loopholes that existed in the scope section of the text, China voiced concerns with language that allowed for the European Union to join as regional integration organizations to assist the implementation of the treaty and Syria criticized the text for being unbalanced.

The Russian delegation voiced concerns about a lack of barriers or obstacles for deadly weapons falling into the hands of terrorists and armed criminals.

But perhaps the biggest surprise of the day came from United States.? The host country had stated its hope for passing a consensus text, but in the final hours raised several concerns, which the delegations described as ?issues, which are of substance but not a huge controversy.?? This put the American delegation ? which some say faltered because the country is facing an election year ? in the company of Syria, Russia and DPRK among other nations that called for more time before agreeing on a consensus text.

?President Obama should have?but did not?provided the leadership necessary to close the deal on the arms trade treaty and help reduce human suffering caused?irresponsible international arms transfers and arms brokering,? said Daryl G. Kimball, Executive Director of the Washington-based Arms Control Association.

A report of the treaty negotiations will now be delivered to the General Assembly, which delivered the conference?s mandate, and countries will decide how to proceed.

?I think this is a time for people to sit down, think about it and make sure the next steps are the logical steps,? said Roberto Dondisch the head treaty negotiator for Mexico.? ?I think it?s a little bit early to say today what are the next steps but I can be sure that Mexico will take the next steps.? We want a strong Arms Trade Treaty.?

Mexico released a statement along with 90 other countries including the European Union and many African states to remain committed to secure an Arms Trade Treaty as soon as possible.

April Warren is an international Journalist based in the United Nations. She is Morocco World News Co-editor

Source: http://www.moroccoworldnews.com/2012/07/49585/un-fails-to-reach-consensus-on-arms-trade-treaty/

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Just Married!: Rochelle Wiseman & Marvin Humes Tie The Knot!

Just Married!: Rochelle Wiseman & Marvin Humes Tie The Knot!

Marvin Humes and Rochelle Wiseman tied the knot on Friday. The JLS star and The Saturdays singer married at the historic Blenheim Palace in Oxfordshire, [...]

Just Married!: Rochelle Wiseman & Marvin Humes Tie The Knot! Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2012/07/110315/

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Israel eyes austerity after prosperous year

Prime Minister Benjamin Netanyahu, who has long boasted how Israel has avoided the fiscal fate of Spain and Greece, is poised to unveil tough austerity measures likely to hit the underprivileged.

The measures will aim to make up part of the budget deficit that has climbed to 4.0 percent of Israel's GDP -- twice that which was expected for 2012.

Taxes on cigarettes and beer have already been hiked this week, and according to media reports the government will also be raising VAT from 16 to 17 percent and introducing a 2.0 percent income tax rise in households with an annual income of at least a million shekels ($245,000, 199,300 euros).

Also expected is a combined 700-million-shekel ($171 million, 140 million euro) cut from the budgets of all ministries with the exception of defence, education and welfare.

A spokesman for Netanyahu told public radio on Thursday that the projected measures would raise the annual tax burden of each Israeli household by 1,740 shekels ($426/347 euros).

But these could only be the beginning, with Finance Minister Yuval Steinitz preparing an additional series of tax rises for 2013.

"There are no free lunches," Netanyahu said this week in an attempt to justify the austerity plan.

The government, he said, had to increase its income to fund free childcare from the age of three, to build a security fence along its southern border with Egypt to stop illegal immigrants, and to acquire "new weapons and defence systems to cope with new threats."

And earlier this week, he also suggested the defence budget could rise even further because of regional developments, notably in Syria.

Beyond the increased expenditure, tax revenues have dropped because of slow economic growth, which is 3.1 percent so far this year compared with 4.8 percent in 2011.

"Those who say that we can spend lavishly... endanger the state of Israel and could easily lead it to the brink of bankruptcy, as is the case of leading European economies," Netanyahu said.

Israeli officials also fear that the major international rating agencies, which had hitherto provided Israel with a clean bill of health, will lower their ratings.

Until now, the Jewish state had effectively escaped the sub prime crisis of 2008 and the beginning of the current crisis in the eurozone.

"To ensure stability, we must take unpopular measures," said Harel Locker, director general of Netanyahu's office.

The bitter pill the government is about to prescribe has been harshly criticised as unjust by the opposition, by the Histadrut trade union confederation and by leaders of the social protest movement which emerged in summer 2011 over the rising cost of living.

And even within the coalition, several religious and ultra-nationalist parties denounced the "anti-social" character of Netanyahu's plan for 2013, an election year.

It is the planned increase in Value Added Tax (VAT), which will affect all Israelis, that has come in for the harshest criticism.

Oded Shahar, an economic commentator for Israeli public television, called it "daylight robbery."

And Sever Plocker of the top-selling daily Yediot Aharonot said the hike was not the fault of "the European crisis" but was because of "the blindness" of the Israeli government.

One of the main critiques levelled at Netanyahu is his intention to give a huge "gift" to multinationals by halving the taxes on monies earned in Israel and which are transferred abroad, from 25 percent to 12 percent.

The Treasury justified the move, saying it would encourage the firms to repatriate their profits rather than having them "sleep" in Israeli banks -- which brings nothing to the taxman.

In a defensive statement on Thursday, Netanyahu said that "even after the steps we will take, families in Israel -- middle-class and underprivileged -- will remain with more money in their pockets" thanks to measures such as free education from the age of three, tax benefits for working families and free dental care for children.

And central bank chief Stanley Fischer was quoted as saying that Netanyahu's planned measures were "very serious progress" which displayed "very responsible leadership by the economic decision-makers."

Source: http://news.yahoo.com/israel-eyes-austerity-prosperous-085944675.html

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Glasgow Rangers move to fourth tier approved

Associated Press Sports

updated 6:39 p.m. ET July 27, 2012

GLASGOW, Scotland (AP) - Glasgow Rangers will begin next season in the fourth tier, Scotland's lowest professional league, after the move was approved by the country's soccer authorities on Friday.

The Scottish Football League announced that agreement had been reached following weeks of discussions to allow a reformed Rangers conditional membership in the Scottish Football Association.

Rangers, Scottish champion a record 54 times, were put in bankruptcy protection because of tax debts exceeding $30 million. The team is now set to visit grounds with seats for just a few hundred fans next season.

Americans Carlos Bocanegra, Maurice Edu and Alejandro Bedoya are on Rangers but may leave.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Terry not off hook in racism case

PST: The British courts have had their say on the alleged John Terry ugliness, but now England?s FA will have something more to say about it.

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PST: All-Star week epitomizes Beckham arrangement

With David Beckham rising to the occasion (remarkably so, given his lack of training), the MLS All-Star Game became a metaphor for league?s entire Beckham experience. For all the worries about his commitment to his North American mission, Beckham was there when it counted.

Source: http://nbcsports.msnbc.com/id/48362063/ns/sports-soccer/

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Wednesday, July 25, 2012

NeurogesX Partner Astellas Enrolls First Patient in EU Clinical Trial ...


Head-to-Head Study Will Compare Qutenza and Pregabalin in the Treatment of Peripheral Neuropathic Pain

ELEVATE Study First to Compare Efficacy, Tolerability and Impact on Quality of Life Versus Pregabalin

SAN MATEO, Calif., July 24, 2012 (MESHPRESS) ? NeurogesX, Inc. (OTCQB:NGSX) (OTCBB:NGSX), a specialty pharmaceutical company focused on developing and commercializing a portfolio of novel non-opioid, pain management therapies, announced today that its partner Astellas Pharma Europe Ltd., the European headquarters of Tokyo-based Astellas Pharma Inc., has enrolled the first patient in its ELEVATE clinical trial in the European Union (EU). This trial is the first study to compare Qutenza? (8% capsaicin patch) to pregabalin as a treatment for peripheral neuropathic pain. Pregabalin is an oral therapy widely used as first-line treatment for peripheral neuropathic pain.[i] Under its Commercial License Agreement with Astellas, NeurogesX shares in the growing market opportunity for Qutenza in the Astellas territory, which includes the EU, the Middle East and Africa, through ongoing royalties, as well as potential sales milestones. In the United States, Qutenza is approved for the management of neuropathic pain associated with post herpetic neuralgia (PHN).

The earliest results of the ELEVATE study, which will evaluate the efficacy and safety of the Qutenza topical patch against pregabalin, are expected in 2014.

Conventional therapies for peripheral neuropathic pain have been limited by negative factors such as systemic side effects, drug-drug interactions, slow onset of action, the need for titration and multiple daily dosing.[ii],[iii],[iv]?The Qutenza patch is designed to act locally on the affected area and has not been associated with the systemic side effects such as sedation and dizziness that may be experienced with other treatments.[ii],[iii],[v]?The ELEVATE study is designed to evaluate which therapy better balances pain relief with tolerability and the ability to return to daily activities.

Associate Professor Maija Haanp??, a Consultant in Pain Management at the Helsinki University Central Hospital, Finland and the lead investigator in the ELEVATE study, commented, ?It is important to perform head-to-head comparative studies, such as this one, in the field of neuropathic pain.?The ELEVATE study may also provide information about the symptom profiles that are most likely to respond to the different treatments since the NPSI* questionnaire, given during the trial, will be used to assess the characteristics of pain and other sensory symptoms.?

The study aims to enroll 526 patients from approximately 100 centers in 23 countries across eastern and western Europe, including the UK, Germany, France, Italy, Spain, Sweden, Finland, Russia, Romania and Bulgaria.[i]

Qutenza uses a synthetic form of capsaicin, the substance found in chili peppers which gives them their ?heat,? to change the way pain-sensing nerves work in the treated area.[vi]?The efficacy and safety of Qutenza have already been investigated in a comprehensive clinical trial program involving 1,327 patients who received at least one application.[v] Pain relief following application of the 8% capsaicin patch can take up to two weeks to take full effect and can be maintained for up to twelve weeks following a single application.[v] Qutenza has caused significant pain reduction when used alone or in combination with other treatments for pain.[v]

The most commonly reported side effects for Qutenza are transient and self-limiting application site reactions, such as pain and erythema that tend to be mild to moderate in intensity.[v]

While the number of patients who suffer from neuropathic pain is not known, estimates typically range from 1 to 2% of the [global] population, while some sources estimate prevalence to be as high as 8%.[vii],[viii]? Peripheral neuropathic pain is a complex and difficult to treat disorder that can have a detrimental effect on a patient?s quality of life.[ix],[x]? Studies suggest that, at present, only one third of patients receiving treatment for neuropathic pain achieve adequate pain relief.[xi] ?Peripheral neuropathic pain is caused by lesion or disease to the peripheral somatosensory nervous system.?The somatosensory system is a diverse sensory system composed of the receptors and processing centers to provide information about touch or pressure, temperature, body position and pain.?The nerve damage that can lead to peripheral neuropathic pain can happen as a result of a range of different diseases, medications or traumatic injuries.

*The Neuropathic Pain Symptom Inventory (NPSI) is self-questionnaire specifically designed to evaluate the different symptoms of neuropathic pain.

About the ELEVATE study

ELEVATE is an open-label study that is planned to enroll 526 adult subjects with moderate-to-severe peripheral neuropathic pain (baseline diagnosis of post-herpetic neuralgia, peripheral nerve injury, or non-diabetic painful peripheral polyneuropathy).[i] Patients in the trial will randomly receive either a single application of up to four 8% capsaicin patches or daily administration of an optimal dose of oral pregabalin (up-titration from 75 mg/day to 150?600 mg/day) for 8 weeks.?Patients enrolled into the study will be either naive to treatment with 8% capsaicin patch, pregabalin and gabapentin or will not have previously received an adequate trial or treatment with pregabalin or gabapentin.?The study will include the following key endpoints: [i]

  • The level of pain relief, as measured by the proportion of subjects in each arm who achieve at least a 30% decrease in the ?average pain for the past 24 hours? Numeric Pain Rating Scale score from baseline to Week 8.
  • The overall therapeutic effect; assessed using a composite endpoint which includes pain relief, adverse events and treatment discontinuation.

About Qutenza

Qutenza? (capsaicin) 8% patch is approved by the European Medicines Agency for the treatment of peripheral neuropathic pain in non-diabetic adults either alone or in combination with other medicinal products for pain. [v] The 8% capsaicin patch is available in 21 countries across Europe as of the end of 2011. Phase 3 clinical studies in painful diabetic neuropathy (PDN) and long-term safety studies are ongoing. Qutenza is approved by the?U.S. Food and Drug Administration?(FDA) for the management of neuropathic pain associated with postherpetic neuralgia (PHN).

The patch delivers a high-dose of a synthetic form of capsaicin directly to the damaged pain sensing nerves in the skin that are the source of neuropathic pain.?Applied to the area of pain, the high concentration of capsaicin contained in the treatment is released into the skin where it overstimulates the pain sensing nerves.?Overstimulating the pain sensing nerves makes them become ?defunctionalized,? effectively reducing their spontaneous activity and making them unresponsive to stimuli that normally cause pain for patients with peripheral neuropathic pain.[xii]

About Astellas Pharma Europe Ltd.

Astellas Pharma Europe Ltd., located in the UK, is the European headquarters of Tokyo-based Astellas Pharma Inc. Astellas is a pharmaceutical company dedicated to improving the health of people around the world through the provision of innovative and reliable pharmaceuticals.?The organisation is committed to becoming a global company by combining outstanding RD and marketing capabilities and continuing to grow in the world pharmaceutical market.?Astellas Pharma Europe Ltd. is responsible for 21 affiliate offices located across Europe, the Middle East and Africa, an RD site and three manufacturing plants.?The company employs approximately 4,200 staff across these regions. For more information about Astellas Pharma Europe, please visit www.astellas.eu.

About NeurogesX

NeurogesX, Inc. (OTCQB:NGSX) (OTCBB:NGSX) is a specialty pharmaceutical company focused on developing and commercializing a portfolio of novel non-opioid, pain management therapies to address unmet medical needs and improve patients? quality of life.

The Company?s lead product, Qutenza?, is currently approved in the United States and the European Union. Qutenza? is now available in the United States for the management of neuropathic pain associated with postherpetic neuralgia (PHN).?In Europe, Qutenza? is being marketed by Astellas Pharma Europe Ltd. (Astellas), the European affiliate of Tokyo-based Astellas Pharma Inc., for the treatment of peripheral neuropathic pain in non-diabetic adults, either alone or in combination with other medicinal products for pain.

The Company?s most advanced product candidate, NGX-1998, is a topically applied liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions such as PHN. NGX-1998 has completed three Phase 1 clinical trials and one Phase 2 clinical trial in PHN patients, and the Company believes that NGX-1998 is ready to enter Phase 3 development.

The Company?s early-stage pipeline includes pre-clinical compounds which include a number of prodrugs of acetaminophen.?The Company has evaluated certain of these compounds in vitro and in vivo.

Safe Harbor Statement

This press release contains forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the Act).?NeurogesX disclaims any intent or obligation to update these forward-looking statements, and claims the protection of the Safe Harbor for forward-looking statements contained in the Act.?Examples of such statements include but are not limited to statements regarding: expected timing of earliest results in 2014 for the ELEVATE study; and NGX-1998 being ready for entry into Phase 3 development.?Such statements are based on management?s current expectations, but actual results may differ materially due to various risks and uncertainties, including, but not limited to: difficulties or delays in carrying out further clinical testing for Qutenza, including difficulties in enrolling patients; NGX-1998 may fail to demonstrate sufficient safety or efficacy in clinical trials to support further development or potential marketing approval; difficulties or delays in further clinical development of NGX-1998, including difficulties or delays in initiating Phase 3 clinical trials; adverse outcomes with respect to, or delay of, the End-of-Phase 2 meeting with the FDA; market acceptance of Qutenza in already approved indications may not be sufficient to support further pursuit of commercialization of Qutenza or could have an effect on NeurogesX? development or other plans with respect to NGX-1998; Qutenza, NGX-1998 and NeurogesX? other product candidates may have unexpected adverse side effects; delay or prevention of commercialization or development activities due to unexpected expenses or a lack of sufficient resources; and difficulties or delays in identifying potential strategic partners for Qutenza and NGX-1998 and negotiating and entering into agreements with such entities.?For further information regarding these and other risks related to NeurogesX? business, investors should consult NeurogesX? filings with the Securities and Exchange Commission.

References

[i]??????? EU Clinical Trials Register: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2011-005872-41Last accessed: May 2012

[ii]?????? Backonja M et al. NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study. Lancet Neurol 2008;7(12):1106-12

[iii] ???? Simpson DM et al. Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathy. Neurology 2008;70(24):2305-13

[iv] ???? O?Connor AB et al. Treatment of neuropathic pain: an overview of recent guidelines. Am J Med 2009;122:S22-32

[v]?????? Qutenza (Capsaicin) EPAR. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000909/WC500040453.pdf Last accessed: April 2012

[vi]????? Knotkova H et al. Capsaicin (TRPV1 agonist) therapy for pain relief: Farewell or revival? Clin J Pain 2008;24(2):142-154

[vii]???? National Institute for Health and Clinical Excellence (NICE) Neuropathic Pain: The pharmacological management of neuropathic pain in adults in non-specialist settings. March 2010. Available from: http://www.nice.org.uk/nicemedia/live/12948/47949/47949.pdf. Last accessed: April 2012

[viii] ?? Mailis Gagnon A et al. Systematic review of the prevalence of neuropathic pain. Eur J Pain 2007;11 (Suppl. 1):S202-S203 [Abstract No. 457]

[ix]????? G?lvez R et al. Cross-sectional evaluation of patient functioning and health-related quality of life in patient with neuropathic pain under standard care conditions. Eur J of Pain 2007;3:244-55

[x] ????? Smith B et al. Health and quality of life associated with chronic pain of predominantly neuropathic origin in the community. Clin J Pain 2007;23:143?9

[xi]????? Jensen T et al. Pharmacology and treatment of neuropathic pains. Current Opinion in Neurology 2009;22:467-474

[xii] ??? Anand P et al. Topical capsacin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch. Br J Anaesth 2011;107(4):490-502

CONTACT: NeurogesX, Inc.          Stephen Ghiglieri          Executive Vice President, COO and CFO          (650) 358-3310          sghiglieri@neurogesx.com           Additional Contacts:          The Ruth Group          Stephanie Carrington / Nicole Greenbaum (investors)          (646) 536-7017 / 7009          scarrington@theruthgroup.com / ngreenbaum@theruthgroup.com           Victoria Aguiar (media)          (646) 536-7013          vaguiar@theruthgroup.com

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Source: http://meshpress.com/neurogesx-partner-astellas-enrolls-first-patient-in-eu-clinical-trial-for-qutenzar-8-capsaicin-patch/127340.html

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Monday, July 23, 2012

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